Medulloblastoma originated from the remaining embryo cells of the reproductive center on top of the fourth ventricle in children ( 8/ 2) and from cells in the external granular layer beneath the cerebellar pia mater on the cerebellar surface in adults. 髓母细胞瘤儿童多起自四脑室顶部髓帆生殖中心的胚胎残余细胞(8/2),成人多源于小脑软膜下原始的外颗粒层细胞,以实性为主。
Basket cells and stellate cells were all originated from the external granular layer, their differentiations occured much later. 蓝细胞与星状细胞均起源于外颗粒层,分化较迟。
Correspondingly, the same trend was found in the primary cultures of rat cortical neurons. Furthermore, high level expression of miR-34a was found in the external granular layer and outer pyramidal layer ( II/ III layers). 相同的表达趋势也存在于大鼠胚胎脑皮层原代培养神经元中,且mir-34a高表达主要集中在皮层颗粒细胞和锥体神经元(Ⅱ/Ⅲ层)。
CSD cRNA signals are broadly expressed in adult mouse brain mantle with high density, and locate in molecular layer, external granular layer, external pyramidal layer, inner granular layer, inner pyramidal layer, and polymorphous cell layer of mouse brain cortex. ⑸CSD阳性信号广泛分布于小鼠大脑皮质区分子层、外颗粒层、外锥体细胞层、内颗粒层、内锥体层和多形细胞层。
In external granular layer of light exposure groups, dispersed positive cells can be seen, which show granular yellow or brown and was located in the nucleus. Partial brink of nucleus was heavily stained and lightly in central, referring to a ring appearance. 光照后各组外颗粒层出现散在分布的阳性表达细胞,表现为颗粒状黄色或棕黄色着色,定位于细胞核,部分胞核边缘着色深,中央着色浅,呈指环状外观。